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Sara T. Winokur, Ph.D

Biological Chemistry
202 Sprague Hall
University of CA, Irvine
Irvine, CA 92697-4041

Telephone: (949) 824-2750
Fax: (949) 824-9547


link to uci


Masny PS, Bengtsson U, Chung SA, Martin JH, Van Engelen B, Van Der Maarel SM, Winokur ST (2004) Localization of 4q35.2 to the nuclear periphery: Is FSHD a nuclear envelope disease? Hum Mol Genet. 13(17):1857-1871

Sara Winokur, Yi- Wen Chen (2004) "Expression Profiling Of FSHD"
Book: Facioscapulohumeral Muscular Dystrophy (FSHD): Clinical Medicine and Molecular Cell Biology. Editors: M. Upadhyaya & D.N. Cooper

Petra G M van Overveld, Richard J F L Lemmers, Lodewijk A Sandkuijl, Leo Enthoven, Sara T Winokur, Floor Bakels, George W Padberg, Gert-Jan B van Ommen, Rune R Frants & Silvère M van der Maarel (2003) Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy. Nat Genet. 35(4):315-7

Winokur ST, Chen Y-W, Masny P, Martin JH, Ehmsen JE, Tapscott SJ, van der Maarel SM, Hayashi Y, and Flanigan KM (2003) Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation. Hum Mol Genet. 12(22):2895-907 ...... link to supplemental data

Winokur ST, Barrett K, Martin JH, Forrester JR, Simon M, Tawil R, Chung S-A, Masny PS and Figlewicz DA (2003) Facioscapulohumeral muscular dystrophy (FSHD) myoblasts demonstrate increased susceptibility to oxidative stress. Neuromuscular Disorders 13(4):322-33 ------link to supplemental data

Tsien F, Sun B, Hopkins NE, Vedanarayanan V, Figlewicz D, Winokur S, and Ehrlich M (2001) Hypermethylation of the FSHD syndrome-associated D4Z4 repeat in normal and FSHD somatic cell populations but not in ICF syndrome cells. Molecular Genetics and Metabolism 74(3):322-31 link to pubmed

Nishizuka, S, Winokur, ST, Simon, M, Martin, JH, Tsujimoto H and Stanbridge EJ (2001) Gene expression profiling using synthetic oligonucleotide arrays in tumorigenic and non tumorigenic HeLa x human fibroblasts. Cancer Letters 165 201-209 link to pubmed

Parseghian MH, Newcomb RL, Winokur ST, Hamkalo BA (2000) The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. Chromosome Res8(5):405-24 link to pubmed

Winokur, ST and Shiang R (1998) The Treacher Collins syndrome (TCOF1) gene product, treacle, is localized to the nucleolus by signals in its carboxy terminus. Hum Molecular Genetics 7 (12): 1947-52 link to pubmed

Xia H, Winokur, ST, Kuo W-L, and Bredt (1997) Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. J. Cell Biology 139(2):507-15 link to pubmed

Winokur, ST, Bengtsson U, Vargas JC, Wasmuth JJ and Altherr MR (1996) The evolutionary distribution and structural organization of the homeobox-containing repeat D4Z4 indicates a functional role for the ancestral copy in the FSHD region. Hum Molecular Genetics 5:1567-1575 link to pubmed

Altherr MR, Bengtsson, U, Makovich RP and Winokur, ST (1995) Efforts towards understanding the molecular basis of facioscapulohumeral muscular dystrophy. Muscle and Nerve S2: S73-78

Weiffenbach B, Dubois J, Manning S, Ma NS, Schutte BC, Winokur, ST, Altherr MR, Jacobsen SJ, Stanton VP Jr,Yokoyama K and Moir D (1994) YAC contigs for 4q35 in the region of the facioscapulohumeral muscular dystrophy (FSHD) gene. Genomics 19: 532-541 link to pubmed

Bengtsson U, Wasmuth JJ, Altherr MA and Winokur, ST (1994) High resolution fluorescence in situ hybridization to linearly extended DNA visually maps a tandem repeat associated with facioscapulohumeral muscular dystrophy immediately adjacent to the telomere of 4q. Human Molecular Genetics 3: 1801-1805 link to pubmed

Shiang R, Thompson LM, Zhu Y-Z, Church DM, Fielder TJ, Bocian M, Winokur, ST and Wasmuth JJ (1994) Mutations in the transmembrane domain of fibroblast growth factor receptor 3 (FGFR3) cause the most common genetic form of dwarfism, achondroplasia. Cell 78:335-342 link to pubmed

Winokur, ST, Bengtsson U, Feddersen J, Mathews KD, Markovich R, Weiffenbach B, Bailey H, Murray JC, Wasmuth JJ, Altherr MR and Schutte BC (1994) The DNA rearrangement associated with facioscapulohumeral muscular dystrophy involves a heterochromatin-associated repetitive element: Implications for a role of chromatin structure in the pathogenesis of the disease. Chromosome Research 2: 225-234 link to pubmed

Weiffenbach B, Dubois J, Storvick D, Tawil R, Jacobsen SJ, Gilbert J, Wijmenga C, Mendell JR, Winokur, ST, Altherr MR, Schultz P, Olandt S, Frants RR, Pericak-Vance M and Griggs RC (1993) Recombination events at 4q35 complicate efforts to localize the FSHD gene. Nature Genetics 4(2):165-9 link to pubmed

Wijmenga C, Winokur, ST, Frants RR, Scholte HR, Van den Bogert C, Skraastad MI, Altherr MR, Wasmuth JJ, Murray JC, Hofker MH and Padberg GW (1993) The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus. Human Genetics 92: 198-203 link to pubmed

Winokur, ST, Schutte B, Weiffenbach B, Washington S, Chakravarti A, Wasmuth JJ and Altherr MR (1993) A radiation hybrid map of fifteen loci on the distal long arm of chromosome 4, the region containing the gene responsible for facioscapulohumeral muscular dystrophy. American Journal of Human Genetics 53: 874-880 link to pubmed